HUMAN NEUROANATOMY (26:112:629)
Instructor: Laszlo Zaborszky, MD,PhD
(zaborszky@axon.rutgers.edu . T:973-353-1080/ ext. 1381)
Semester: Fall 2005
Credit: 3 units
Day&Time : Wednesday 1:30-4:30
Place: Aidekman Seminar Room B
Organizational Meeting: September 7, 1:30 PM
Course Description
The human brain will be covered in detail. The course format will be a combination of lectures and laboratory sessions and will consist of three major parts. Part 1 will include the development of the nervous system, brain dissection, imaging and neuroanatomical techniques. Extra session will be devoted to CNS vasculature, including cerebrovascular diseases. Part 2 deals with the somatosensory and motor systems, including motor disorders. Part 3 will overview the functional anatomical basis of cognitive functions, including sensory-motor integration, memory, emotion, motivation and attention. An important goal of this course is to familiarize the students with functionally relevant anatomical features, to study the principles of organization of the brain and get an insight how ‘structural’, ‘effective’ and ‘functional’ connectivity relate to each other. Readings draw from classical papers in the field and short papers, discussing human imaging studies.
Enrollment
No more than 10 students. The course is open to graduate students, provided that they have already taken Foundations of Neuroscience (26:112:565) or Neurophysiology & Behavior (26:830:597). Undergraduates can enroll by permission of the instructor. Prior courses such as Anatomy & Physiology (21:120:241), Mammalian Physiology (21:120:340) or Comparative Anatomy of Vertebrates (21&62:120:320) are required.
Requirements
Course grade will be based 1) a paper on any topic relevant to the course; 2) two short presentations; 3) written exams (2 midterm, 1 final) consisting of multiple choice questions and short essays; 4) final oral and practical exam.
HUMAN NEUROANATOMY SYLLABUS
BASIC DESIGN OF THE NERVOUS SYSTEM
1. Fundamentals of the CNS. The Neuron Doctrine
2. Brain Dissection I. DVD
3. Brain Dissection II Laboratory
4. Meninges and Cerebrospinal Fluid. Blood Brain Barrier. Cerebrovascular Diseases.
5. Neuroanatomical Tracing and Functional Imaging Techniques
6. Development as a Guide to the Regional Anatomy of the Brain
7. Organization of the Spinal Cord, Brainstem and Forebrain
8. Review Questions
FUNCTIONAL ANATOMY OF THE SOMATOSENSORY, VISUAL, AND MOTOR SYSTEMS
9. Somatic Sensory Systems
10. Organization of the Descending Motor Pathways
11. The Basal Ganglia and Diseases of the "Extrapyramidal" System
12 Cerebellum.
13. Thalamus
14. The Visual System
15. Review Questions
COGNITIVE NEUROANATOMY
16. Subcortical Activating Systems I. NE, 5HT, DA, Mesopontine Tegmentum
17. Subcortical Activating Systems II. Histamin, Orexin, Basal Forebrain. Sleep-Wakefulness
18. Hypothalamus. Stress and Cognition
19. Amygdala. Emotion. The Limbic System Concept
20. Functional Organization of the Cerebral Cortex
21. Focal lesions, Apahasia, Agnosia, Apraxia
22. The Motor cortex and Sensory-Motor Integratioon
23. The Prefrontal Cortex. Frontal-Subcortical Circuits. Executive Functionsand Behavior
24. Hippocampus. Amnesias with Hippocampal Lesions
25. Attentional Networks. Neglect Syndrome
26. Review Questions
SUGGESTED READING:
Nolte: The Human Brain. An Introduction to its Functional Anatomy, Mosby, 2002
Frackowiak et al: Human Brain Function, Elsevier, 2004