Fall 2005 Integrative Neuroscience Program

HUMAN NEUROANATOMY  (26:112:629)

 Instructor: Laszlo Zaborszky, MD,PhD

(zaborszky@axon.rutgers.edu . T:973-353-1080/ ext. 1381)

Semester: Fall 2005

Credit: 3 units

Day&Time : Wednesday 1:30-4:30

Place: Aidekman Seminar Room B

Organizational Meeting: September 7, 1:30 PM

 

Course Description

 The human brain will be covered in detail. The course format will be a combination of lectures and laboratory sessions and will consist of three major parts. Part 1 will include the development of the nervous system, brain dissection, imaging and neuroanatomical techniques. Extra session will be devoted to CNS vasculature, including cerebrovascular diseases.  Part 2 deals with the somatosensory and motor systems, including motor disorders. Part 3 will overview the functional anatomical basis of cognitive functions, including sensory-motor integration, memory, emotion, motivation and attention. An important goal of this course is to familiarize the students with functionally relevant anatomical features, to study the principles of organization of the brain and get an insight how ‘structural’, ‘effective’ and ‘functional’ connectivity relate to each other. Readings draw from classical papers in the field and short papers, discussing human imaging studies.

 

Enrollment

 No more than 10 students. The course is open to graduate students, provided that they have already taken Foundations of Neuroscience (26:112:565) or Neurophysiology & Behavior (26:830:597). Undergraduates can enroll by permission of the instructor. Prior courses such as Anatomy & Physiology (21:120:241), Mammalian Physiology (21:120:340) or Comparative Anatomy of Vertebrates (21&62:120:320) are required.

 

Requirements

Course grade will be based 1) a paper on any topic relevant to the course; 2) two short presentations; 3) written exams (2 midterm, 1 final) consisting of multiple choice questions and short essays; 4) final oral and practical exam.


HUMAN NEUROANATOMY SYLLABUS

BASIC DESIGN OF THE NERVOUS SYSTEM

 

            1. Fundamentals of the CNS. The Neuron Doctrine

            2. Brain Dissection I.  DVD

            3. Brain Dissection II  Laboratory

            4. Meninges and Cerebrospinal Fluid. Blood Brain Barrier. Cerebrovascular Diseases.

            5. Neuroanatomical Tracing and Functional Imaging Techniques

            6. Development as a Guide to the Regional Anatomy of the Brain

             7. Organization of the Spinal Cord, Brainstem and Forebrain

             8. Review Questions

 

FUNCTIONAL ANATOMY OF THE SOMATOSENSORY, VISUAL, AND MOTOR SYSTEMS

 

9.  Somatic Sensory Systems

10. Organization of the Descending Motor Pathways

            11. The Basal Ganglia and Diseases of the "Extrapyramidal" System

            12  Cerebellum.

            13. Thalamus

            14. The Visual System

            15. Review Questions

             

COGNITIVE NEUROANATOMY

 

            16. Subcortical Activating Systems I. NE, 5HT, DA, Mesopontine Tegmentum

            17. Subcortical Activating Systems II. Histamin, Orexin, Basal Forebrain. Sleep-Wakefulness

            18. Hypothalamus. Stress and Cognition

            19. Amygdala. Emotion. The Limbic System Concept    

            20. Functional Organization of the Cerebral Cortex

            21. Focal lesions, Apahasia, Agnosia, Apraxia

            22. The Motor cortex and Sensory-Motor Integratioon

            23. The Prefrontal Cortex. Frontal-Subcortical Circuits. Executive Functionsand Behavior

            24. Hippocampus. Amnesias with Hippocampal Lesions             

            25. Attentional  Networks. Neglect Syndrome

            26. Review Questions

 

 

SUGGESTED READING:

 

Nolte: The Human Brain. An Introduction to its Functional Anatomy, Mosby, 2002

 

Frackowiak et al: Human Brain Function, Elsevier, 2004

 

Human NA Lectures